Synthesis and Characterization of a Library of In‐Situ Curing, Nonswelling Ethoxylated Polyol Thiol‐ene Hydrogels for Tailorable Macromolecule Delivery. (10th November 2014)

• Record Type: Journal Article
• Authors: O'Shea, Timothy M.; Aimetti, Alex A.; Kim, Eunha; Yesilyurt, Volkan; Langer, Robert
• Is Part Of: Advanced materials. Volume 27:Number 1(2014)
• Page Start: 65
• Page End: 72
• Publication Date: 2014-11-10
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201403724
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201403724-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A transesterfication reaction</bold> is used to synthesize tri‐thiol‐functionalized‐ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume‐constrained anatomical sites. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh30v92djq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>