Factors associated with postoperative hypothyroidism after lobectomy in papillary thyroid microcarcinoma patients. (February 2015)

• Record Type: Journal Article
• Authors: Park, Ha Kyoung; Kim, Dong Wook; Ha, Tae Kwun; Choo, Hye Jung; Park, Young Mi; Jung, Soo Jin; Kim, Do Hun; Bae, Sang Kyun
• Is Part Of: Endocrine research. Volume 40:Number 1(2015:Feb.)
• Page Start: 49
• Page End: 53
• Publication Date: 2015-02
• Subjects: Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2014.933975
• Languages: English
• ISSNs: 0743-5800

Abstract

<abstract> <title>ABSTRACT</title> <p> <italic>Purpose</italic>: No previous study regarding the correlation between post-operative thyroid function and underlying thyroid histopathology has been published. This study assessed the relationship between postoperative thyroid function after lobectomy and multiple factors in papillary thyroid microcarcinoma (PTMC) patients. <italic>Materials and methods</italic>: From January 2010 to December 2010, 338 patients who had undergone thyroid lobectomy for PTMC were enrolled. Patients with pre-operative hyperthyroidism or those with hypothyroidism but no pre-operative serological data were excluded, leaving a cohort of 285 patients. The relationships between post-operative thyroid function (based on successful cessation of thyroxine replacement therapy) and multiple factors (patient age and sex, serological data, the Pre-operative anteroposterior diameter of the thyroid gland, underlying histopathology of the thyroid gland, and number of attempts to stop thyroxine replacement therapy) were analyzed. <italic>Results</italic>: Out of 285 patients, 157 attempted to stop thyroxine replacement therapy once or twice after lobectomy; 91 successfully stopped thyroxine replacement therapy during the study period. The final histopathologic diagnoses after surgery included Hashimoto's thyroiditis (<italic>n</italic> = 5), non-Hashimoto type of lymphocytic thyroiditis (<italic>n</italic> = 17), and normal thyroid parenchyma (<italic>n</italic> = 135). Pre-operative thyroid-stimulating hormone (TSH) levels differed significantly between patients with postoperative hypothyroidism and those with postoperative euthyroidism (univariate logistic regression analysis, <italic>p</italic> = 0.0028; multivariate logistic regression analysis, <italic>p</italic> = 0.0029). No statistically significant differences were found for any other factors. <italic>Conclusions</italic>: The study results demonstrated that the Pre-operative TSH level was the only predictor for the development of post-operative hypothyroidism after thyroid lobectomy in PTMC patients.</p> </abstract>