Inside Cover: Covalent Inhibition of New Delhi Metallo‐β‐Lactamase‐1 (NDM‐1) by Cefaclor (ChemBioChem 17/2014). Issue 17 (24th November 2014)

• Record Type: Journal Article
• Authors: Thomas, Pei W.; Cammarata, Michael; Brodbelt, Jennifer S.; Fast, Walter
• Is Part Of: Chembiochem. Volume 15:Issue 17(2014)
• Page Start: 2474
• Page End: 2474
• Publication Date: 2014-11-24
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201490059
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> The inside cover picture shows a visual metaphor for the unsuccessful use of covalent serine β‐lactamase inactivators to inhibit NDM‐1, which uses a noncovalent catalytic mechanism. In contrast, W. Fast and co‐workers (see <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 2541 ff.)</ext-link> have identified Lys211 as a suitable "handhold" for covalent inhibition. (Image by B. Lehmkuhle).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2cpvhnb7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>