Gold(I) Catalysis at Extreme Concentrations Inside Self‐Assembled Nanospheres1. Issue 49 (12th September 2014)

• Record Type: Journal Article
• Authors: Gramage‐Doria, Rafael; Hessels, Joeri; Leenders, Stefan H. A. M.; Tröppner, Oliver; Dürr, Maximilian; Ivanović‐Burmazović, Ivana; Reek, Joost N. H.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 49(2014)
• Page Start: 13380
• Page End: 13384
• Publication Date: 2014-09-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201406415
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Homogeneous transition‐metal catalysis is a crucial technology for the sustainable preparation of valuable chemicals. The catalyst concentration is usually kept as low as possible, typically at m<sc>M</sc> or μ<sc>M</sc> levels, and the effect of high catalyst concentration is hardly exploited because of solubility issues and the inherent unfavorable catalyst/substrate ratio. Herein, a self‐assembly strategy is reported which leads to local catalyst concentrations ranging from 0.05 <sc>M</sc> to 1.1 <sc>M</sc>, inside well‐defined nanospheres, whilst the overall catalyst concentration in solution remains at the conventional m<sc>M</sc> levels. We disclose that only at this high concentration, the gold(I) chloride is reactive and shows high selectivity in intramolecular CO and CC bond‐forming cyclization reactions.</p> </abstract>