A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA. Issue 8 (August 2013)

• Record Type: Journal Article
• Authors: Akita, Hidetaka; Ishiba, Ryohei; Hatakeyama, Hiroto; Tanaka, Hiroki; Sato, Yusuke; Tange, Kota; Arai, Masaya; Kubo, Kazuhiro; Harashima, Hideyoshi
• Is Part Of: Advanced healthcare materials. Volume 2:Issue 8(2013:Aug.)
• Page Start: 1120
• Page End: 1125
• Publication Date: 2013-08
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201200431
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>SS‐cleavable proton‐activated lipid‐like material (ssPalm) functions as a key element in a lipid nanoparticle</bold> in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton‐sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol). <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2cgcxtbv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>