Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer. (December 2014)

• Record Type: Journal Article
• Authors: Zhang, Yaping; Qiu, Ling; Wang, Yanmin; He, Chengyan; Qin, Xuzhen; liu, Yujie; Li, Zhili
• Is Part Of: Biomarkers. Volume 19:Number 8(2014)
• Page Start: 667
• Page End: 673
• Publication Date: 2014-12
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.977951
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C_16:1, C_18:3, C_18:2, C_18:1, C_20:4, and C_22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C_16:1, C_18:3, C_18:2, C_20:4, and C_22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.</p> </abstract>