Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet. (December 2014)

• Record Type: Journal Article
• Authors: Fujii, Tatiane Mieko de Meneses; Jacob, Patrícia Silva; Yamada, Monica; Borges, Maria Carolina; Norde, Marina Maintinguer; Pantaleão, Lucas Carminatti; Oliveira, Daniela Moura de; Tirapegui, Julio; Castro, Inar Alves de; Borelli, Primavera; Fock, Ricardo Ambrósio; Rogero, Marcelo Macedo
• Is Part Of: International journal of food sciences and nutrition. Volume 65:Number 8(2014)
• Page Start: 967
• Page End: 976
• Publication Date: 2014-12
• Subjects: Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.3109/09637486.2014.945153
• Languages: English
• ISSNs: 0963-7486

Abstract

<abstract> <title>Abstract</title> <p>To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (<italic>n = </italic>24) or a HFD (<italic>n = </italic>24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (<italic>p</italic> &lt; 0.05) and total blood cholesterol (<italic>p</italic> &lt; 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.</p> </abstract>