Seropositivity of HPV 16 E6 and E7 and the risk of oral cancer. (21st January 2014)

• Record Type: Journal Article
• Authors: Wong, GR; Ha, KO; Himratul‐Aznita, WH; Yang, YH; Wan Mustafa, WM; Yuen, KM; Abraham, MT; Tay, KK; Karen‐Ng, LP; Cheong, SC; Zain, RB
• Is Part Of: Oral diseases. Volume 20:Number 8(2014:Nov.)
• Page Start: 762
• Page End: 767
• Publication Date: 2014-01-21
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12218
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12218-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12218-sec-0001" sec-type="section"> <title>Objectives</title> <p>The objective of the study was to determine the prevalence of HPV seropositivity among patients with oral squamous cell carcinoma (OSCC) and healthy individuals and to correlate the association between HPV 16 seropositivity and risk of OSCC.</p> </sec> <sec id="odi12218-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>HPV 16 E6 and E7 plasmids were constructed for the production of recombinant protein, which was used as the antigen in ELISA. HPV ELISA was performed on serum samples from 50 healthy individuals and 50 patients with OSCC.</p> </sec> <sec id="odi12218-sec-0003" sec-type="section"> <title>Results</title> <p>Using the HPV ELISA, 30% (OR = 2.25, 95% CI = 0.85–5.93) and 18% (OR = 1.61, 95% CI = 0.53–4.92) of patients with oral cancer were found to be HPV 16 E6 and E7 seropositive, respectively. Significant association was found between HPV 16 seropositivity and increased risk of OSCC in men, but not in male subjects. A similar trend was observed in non‐betel quid chewers.</p> </sec> <sec id="odi12218-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Potential associations between HPV 16 E6/E7 seropositivity and oral cancer were revealed in men and non‐betel quid chewer subjects, suggesting a possible etiological role of HPV 16 in subgroup of patients with OSCC in Malaysia.</p> </sec> </abstract>