Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers. (11th September 2014)

• Record Type: Journal Article
• Authors: Bokhari, Syed Akhtar H.; Khan, Ayyaz A.; Butt, Arshad K.; Hanif, Mohammad; Izhar, Mateen; Tatakis, Dimitris N.; Ashfaq, Mohammad
• Is Part Of: Journal of clinical periodontology. Volume 41:Number 11(2014:Nov.)
• Page Start: 1048
• Page End: 1054
• Publication Date: 2014-09-11
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12284
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12284-abs-0001"> <title>Abstract</title> <sec id="jcpe12284-sec-0001" sec-type="section"> <title>Aim</title> <p>Few studies have examined the relationship of individual periodontal parameters with individual systemic biomarkers. This study assessed the possible association between specific clinical parameters of periodontitis and systemic biomarkers of coronary heart disease risk in coronary heart disease patients with periodontitis.</p> </sec> <sec id="jcpe12284-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Angiographically proven coronary heart disease patients with periodontitis (<italic>n</italic> = 317), aged >30 years and without other systemic illness were examined. Periodontal clinical parameters of bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) and systemic levels of high‐sensitivity C‐reactive protein (CRP), fibrinogen (FIB) and white blood cells (WBC) were noted and analyzed to identify associations through linear and stepwise multiple regression analyses.</p> </sec> <sec id="jcpe12284-sec-0003" sec-type="section"> <title>Results</title> <p>Unadjusted linear regression showed significant associations between periodontal and systemic parameters; the strongest association (<italic>r</italic> = 0.629; <italic>p</italic> < 0.001) was found between BOP and CRP levels, the periodontal and systemic inflammation marker, respectively. Stepwise regression analysis models revealed that BOP was a predictor of systemic CRP levels (<italic>p</italic> < 0.0001). BOP was the only periodontal parameter significantly associated with each systemic parameter (CRP, FIB, and WBC).</p> </sec> <sec id="jcpe12284-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In coronary heart disease patients with periodontitis, BOP is strongly associated with systemic CRP levels; this association possibly reflects the potential significance of the local periodontal inflammatory burden for systemic inflammation.</p> </sec> </abstract>