Relationship and factors responsible for regulating fasting and post‐challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus. Issue 6 (12th May 2014)

• Record Type: Journal Article
• Authors: Aoyama‐Sasabe, Sae; Xin, Xin; Taniguchi, Ataru; Nakai, Yoshikatsu; Mitsui, Rie; Tsuji, Hideaki; Yabe, Daisuke; Yasuda, Koichiro; Kurose, Takeshi; Inagaki, Nobuya; Seino, Yutaka; Fukushima, Mitsuo
• Is Part Of: Journal of diabetes investigation. Volume 5:Issue 6(2014:Dec.)
• Page Start: 663
• Page End: 670
• Publication Date: 2014-05-12
• Subjects: Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12239
• Languages: English
• ISSNs: 2040-1116

Abstract

<abstract abstract-type="main" id="jdi12239-abs-0001"> <title>Abstract</title> <sec id="jdi12239-sec-0001" sec-type="section"> <title>Aims/Introduction</title> <p>Elevation of 2‐h plasma glucose (2‐h PG) levels keeps step with fasting plasma glucose (FPG) levels elevation, but some individuals show dominant elevation of 2‐h PG and others FPG. We analyzed dependent and independent relationships between 2‐h PG and FPG, and investigated the factors regulating 2‐h PG and FPG.</p> </sec> <sec id="jdi12239-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>In 1, 657 Japanese participants who underwent a 75‐g oral glucose tolerance test at the initial examination for a medical check‐up, we carried out simple linear regression analysis between 2‐h PG and FPG levels on the three patterns of independent variables. We divided the participants into two subgroups: the 2‐h PG‐side group and the FPG‐side from the regression line, and examined the relationships between 2‐h PG‐FPG and factors responsible for elevation of plasma glucose levels.</p> </sec> <sec id="jdi12239-sec-0003" sec-type="section"> <title>Results</title> <p>There was a significant positive correlation between 2‐h PG and FPG levels. The regression line of both 2‐h PG and FPG as independent variables was in accordance with the regression line of 2‐h PG as an independent variable and FPG as a dependent variable. In 2‐h PG‐side group, age was the independent factor affecting 2‐h PG in addition to insulinogenic index and insulin sensitivity index (ISI composite). In the FPG‐side group, triglyceride was the independent factor affecting FPG in addition to insulinogenic index and ISI composite.</p> </sec> <sec id="jdi12239-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Two‐hour PG was an independent predictor of FPG. In addition to the importance of decreased insulin secretion and insulin sensitivity, age was the strong factor to elevate 2‐h PG levels in the 2‐h PG‐side group and triglyceride was the strong factor to elevate FPG levels in the FPG‐side group in the early stage of development of type 2 diabetes.</p> </sec> </abstract>