Fabp4‐CreER lineage tracing revealstwo distinctive coronary vascular populations. Issue 11 (30th September 2014)

• Record Type: Journal Article
• Authors: He, Lingjuan; Tian, Xueying; Zhang, Hui; Wythe, Joshua D.; Zhou, Bin
• Is Part Of: Journal of cellular and molecular medicine. Volume 18:Issue 11(2014)
• Page Start: 2152
• Page End: 2156
• Publication Date: 2014-09-30
• Subjects: Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.12415
• Languages: English
• ISSNs: 1582-1838

Abstract

<abstract abstract-type="main" id="jcmm12415-abs-0001"> <title>Abstract</title> <p>Over the last two decades, genetic lineage tracing has allowed for the elucidation of the cellular origins and fates during both embryogenesis and in pathological settings in adults. Recent lineage tracing studies using Apln‐CreER tool indicated that a large number of post‐natal coronary vessels do not form from pre‐existing vessels. Instead, they form <italic>de novo</italic> after birth, which represents a coronary vascular population (CVP) distinct from the pre‐existing one. Herein, we present new coronary vasculature lineage tracing results using a novel tool, Fabp4‐CreER. Our results confirm the distinct existence of two unique CVPs. The 1^st CVP, which is labelled by Fabp4‐CreER, arises through angiogenic sprouting of pre‐existing vessels established during early embryogenesis. The 2^nd CVP is not labelled by Fabp4, suggesting that these vessels form <italic>de novo</italic>, rather than through expansion of the 1^st CVP. These results support the <italic>de novo</italic> formation of vessels in the post‐natal heart, which has implications for studies in cardiovascular disease and heart regeneration.</p> </abstract>