Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12). Issue 11 (14th May 2014)

• Record Type: Journal Article
• Authors: Yoshizawa, S.; Heianza, Y.; Arase, Y.; Saito, K.; Hsieh, S. D.; Tsuji, H.; Hanyu, O.; Suzuki, A.; Tanaka, S.; Kodama, S.; Shimano, H.; Hara, S.; Sone, H.
• Is Part Of: Diabetic medicine. Volume 31:Issue 11(2014:Nov.)
• Page Start: 1378
• Page End: 1386
• Publication Date: 2014-05-14
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12471
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12471-abs-0001"> <title>Abstract</title> <sec id="dme12471-sec-0001" sec-type="section"> <title>Aims</title> <p>To examine current BMI and various aspects of BMI history as pre‐screening tools for undiagnosed diabetes in Japanese individuals.</p> </sec> <sec id="dme12471-sec-0002" sec-type="section"> <title>Methods</title> <p>This cross‐sectional study included 16 226 men and 7026 women aged 30–75 years without a self‐reported history of clinician‐diagnosed diabetes. We estimated the probability of having undiagnosed diabetes (fasting glucose ≥ 7.0 mmol/l and/or HbA<sub>1c</sub> ≥ 48 mmol⁄mol (≥ 6.5%) for the following variables: current BMI, BMI in the early 20s (BMI<sub>20y</sub>), lifetime maximum BMI (BMI<sub>max</sub>), change between BMI in the early 20s and current BMI (ΔBMI<sub>20y−cur</sub>), change between BMI in the early 20s and maximum BMI (ΔBMI<sub>20y−max</sub>), and change between lifetime maximum and current BMI (ΔBMI<sub>max−cur</sub>).</p> </sec> <sec id="dme12471-sec-0003" sec-type="section"> <title>Results</title> <p>The prevalence of undiagnosed diabetes was 3.3% (771/23252) among participants. BMI<sub>max</sub>, ΔBMI<sub>20y–max</sub> and current BMI (1‐<sc>sd</sc> increments) were more strongly associated with diabetes than the other factors (multivariate odds ratio 1.58 [95% CI 1.47–1.70] in men and 1.65 [95% CI 1.43–1.90] in women for BMI<sub>max</sub>; multivariate odds ratio 1.47 [95% CI 1.37–1.58] in men and 1.61 [95% CI 1.41–1.84] in women for ΔBMI<sub>20y–max</sub>; multivariate odds ratio 1.47 [95% CI 1.36–1.58] in men and 1.63 [95% CI 1.40‐1.89] in women for current BMI). The probability of having diabetes was markedly higher in those with both the highest tertile of BMI<sub>max</sub> and greatest ΔBMI<sub>20y‐max</sub>; however, a substantially lower likelihood of diabetes was observed among individuals with the lowest and middle tertiles of current BMI (< 24.62 kg/m<sup>2</sup> in men and < 22.54 kg/m<sup>2</sup> in women).</p> </sec> <sec id="dme12471-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Lifetime maximum BMI and BMI changes from early adulthood were strongly associated with undiagnosed diabetes. Adding BMI history to people's current BMI would improve the identification of individuals with a markedly higher probability of having undiagnosed diabetes.</p> </sec> </abstract>