A genetic variant in SLC6A20 is associated with Type 2 diabetes in white‐European and Chinese populations. Issue 11 (12th August 2014)

• Record Type: Journal Article
• Authors: Ling, Y.; van Herpt, T. T. W.; van Hoek, M.; Dehghan, A.; Hofman, A.; Uitterlinden, A. G.; Jiang, S.; Lieverse, A. G.; Bravenboer, B.; Lu, D.; van Duijn, C. M.; Gao, X.; Sijbrands, E. J. G.
• Is Part Of: Diabetic medicine. Volume 31:Issue 11(2014:Nov.)
• Page Start: 1350
• Page End: 1356
• Publication Date: 2014-08-12
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12528
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12528-abs-0001"> <title>Abstract</title> <sec id="dme12528-sec-0001" sec-type="section"> <title>Aims</title> <p>To investigate whether polymorphisms in <italic>SLC6A20</italic> are associated with susceptibility to Type 2 diabetes.</p> </sec> <sec id="dme12528-sec-0002" sec-type="section"> <title>Methods</title> <p>In the Rotterdam Study, a prospective, population‐based cohort (<italic>n </italic>=<italic> </italic>5974), 22 tagging polymorphisms with minor allele frequencies>0.05 across <italic>SLC6A20</italic> were studied. Replication studies were performed in an independent Dutch case–control study (DiaGene‐Rotterdam Study 2 <italic>n </italic>=<italic> </italic>3133), and in a Chinese Han case–control population (<italic>n </italic>=<italic> </italic>2279). A meta‐analysis of the results was performed.</p> </sec> <sec id="dme12528-sec-0003" sec-type="section"> <title>Results</title> <p>In the Rotterdam study, the minor alleles of rs13062383, rs10461016 and rs2286489 increased the risk of Type 2 diabetes (hazard ratio 1.37, 95% CI 1.15–1.63, hazard ratio 1.30 95% CI 1.09–1.54 and hazard ratio 1.20, 95% CI 1.07–1.35, respectively). In the DiaGene/Rotterdam Study 2, the <italic>A</italic> allele of rs13062383 increased the risk of Type 2 diabetes (odds ratio 1.45, 95% CI 1.19–1.76). In the Chinese Han study, the rs13062383 <italic>A</italic> allele also increased the risk of Type 2 diabetes (odds ratio 1.21, 95% CI 1.03–1.42). Meta‐analysis showed a highly significant association of rs13062383 with Type 2 diabetes (odds ratio 1.35, 95% CI 1.21–1.47; <italic>P </italic>=<italic> </italic>3.3 × 10<sup>‐8</sup>).</p> </sec> <sec id="dme12528-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In conclusion, rs13062383 in <italic>SLC6A20</italic> increased the susceptibility to Type 2 diabetes in populations with different genetic backgrounds.</p> </sec> </abstract>