Acute and chronic effects of kisspeptin‐54 administration on GH, prolactin and TSH secretion in healthy women. (25th June 2014)

• Record Type: Journal Article
• Authors: Jayasena, Channa N.; Comninos, Alexander N.; Narayanaswamy, Shakunthala; Bhalla, Sanjana; Abbara, Ali; Ganiyu‐Dada, Zainab; Busbridge, Mark; Ghatei, Mohammad A.; Bloom, Stephen R.; Dhillo, Waljit S.
• Is Part Of: Clinical endocrinology. Volume 81:Number 6(2014:Dec.)
• Page Start: 891
• Page End: 898
• Publication Date: 2014-06-25
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12512
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12512-abs-0001"> <title>Summary</title> <sec id="cen12512-sec-0001" sec-type="section"> <title>Background</title> <p>The peptide hormone kisspeptin is essential for human reproduction, acting on the hypothalamus to stimulate gonadotrophin‐releasing hormone (GnRH) secretion. Kisspeptin is currently being evaluated as a novel therapeutic for women with infertility. However, some animal studies suggest that kisspeptin may also stimulate growth hormone (GH), prolactin and thyroid‐stimulating hormone (TSH) secretion, with implications for its safety; no previous study has investigated whether kisspeptin stimulates these pituitary hormones in humans.</p> </sec> <sec id="cen12512-sec-0002" sec-type="section"> <title>Aim</title> <p>To determine whether kisspeptin‐54 modulates GH, prolactin and TSH secretion in healthy women.</p> </sec> <sec id="cen12512-sec-0003" sec-type="section"> <title>Design and participants</title> <p>Prospective, single‐blinded, placebo‐controlled, one‐way crossover study. Five healthy women received 7 days of twice‐daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin‐54 (month 2).</p> </sec> <sec id="cen12512-sec-0004" sec-type="section"> <title>Measurements</title> <p>Serum samples were analysed post hoc for GH, prolactin and TSH.</p> </sec> <sec id="cen12512-sec-0005" sec-type="section"> <title>Results</title> <p>Mean serum GH, PRL and TSH did not change during the first 4 h following kisspeptin‐54 injection when compared with vehicle. The mean frequency or amplitude of GH pulses (which influence GH function) did not change acutely following kisspeptin‐54 injection when compared with vehicle. No chronic changes in serum GH, PRL or TSH were observed over the 7‐day period of twice‐daily kisspeptin‐54 injections when compared with vehicle.</p> </sec> <sec id="cen12512-sec-0006" sec-type="section"> <title>Conclusion</title> <p>While we cannot exclude any effect of kisspeptin‐54 on GH, prolactin or TSH secretion, we observed no significant changes in these hormones at a dose of kisspeptin‐54 administration known to stimulate gonadotrophin secretion in a small study of healthy women. These data have important implications for the potential of kisspeptin to treat patients with infertility.</p> </sec> </abstract>