Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro. (30th October 2014)

• Record Type: Journal Article
• Authors: Fischer, T.W.; Herczeg‐Lisztes, E.; Funk, W.; Zillikens, D.; Bíró, T.; Paus, R.
• Is Part Of: British journal of dermatology. Volume 171:Number 5(2014:Nov.)
• Page Start: 1031
• Page End: 1043
• Publication Date: 2014-10-30
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.13114
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd13114-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd13114-list-0001" list-type="bullet"> <list-item> <p>Caffeine stimulates hair growth in androgen‐sensitive testosterone‐suppressed male human hair follicles (HFs) <italic>in vitro</italic>.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd13114-list-0002" list-type="bullet"> <list-item> <p>The first evidence is presented for caffeine‐stimulated growth of female human HFs, which are more caffeine sensitive than male HFs.</p> </list-item> <list-item> <p>Proliferation is increased by caffeine in human HF matrix keratinocytes <italic>in situ</italic> and in HF‐derived outer root sheath keratinocytes (ORSKs).</p> </list-item> <list-item> <p>The catagen inducer transforming growth factor‐β2 is downregulated, and the anagen‐promoting factor insulin‐like growth factor‐1 is upregulated in human HFs <italic>in situ</italic> and in ORSKs.</p> </list-item> </list> </p> </abstract>