Early‐onset acral basal cell carcinomas in Gorlin syndrome. (1st October 2014)

• Record Type: Journal Article
• Authors: Torrelo, A.; Vicente, A.; Navarro, L.; Planaguma, M.; Bueno, E.; González‐Sarmiento, R.; Hernández‐Martín, A.; Noguera‐Morel, L.; Requena, L.; Colmenero, I.; Parareda, A.; González‐Enseñat, M.A.; Happle, R.
• Is Part Of: British journal of dermatology. Volume 171:Number 5(2014:Nov.)
• Page Start: 1227
• Page End: 1229
• Publication Date: 2014-10-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.13118
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="main" id="bjd13118-abs-0001"> <title>Summary</title> <p>Two patients are reported in whom early‐onset, distal papules with a histopathological diagnosis of basal cell carcinoma were the first manifestation of Gorlin syndrome (GS). These lesions showed no progression and remained stable through follow‐up. Two different <italic>PTCH1</italic> gene mutations were detected in the two patients, and thus a phenotype–genotype correlation of this manifestation of GS was not possible.</p> </abstract>