Association of tyrosine with insulin resistance in hepatitis C virus‐related chronic liver disease. Issue 10 (27th August 2013)

• Record Type: Journal Article
• Authors: Oono, Takashi; Yamasaki, Takahiro; Zaitsu, Junichi; Saeki, Issei; Iwamoto, Takuya; Harima, Yumiko; Marumoto, Yoshio; Hidaka, Isao; Urata, Yohei; Ishikawa, Tsuyoshi; Takami, Taro; Segawa, Makoto; Uchida, Koichi; Terai, Shuji; Kunitugu, Ichiro; Tanabe, Tsuyoshi; Sakaida, Isao
• Is Part Of: Hepatology research. Volume 44:Issue 10(2014:Oct.)
• Page Start: E54
• Page End: E62
• Publication Date: 2013-08-27
• Subjects: Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12213
• Languages: English
• ISSNs: 1386-6346

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hepr12213-sec-0001" sec-type="section"> <title>Aim</title> <p>Insulin resistance (IR) increases during the early stages of hepatitis C virus (HCV)‐related chronic liver disease and is a sign of poor prognosis as well as a risk factor for hepatic fibrosis and hepatocellular carcinoma. We aimed to determine the factors affecting IR in HCV‐related chronic liver disease.</p> </sec> <sec id="hepr12213-sec-0002" sec-type="section"> <title>Methods</title> <p>We retrospectively examined 71 patients with HCV‐related chronic liver disease and analyzed various parameters, including amino acids, as possible predictors of IR. IR was assessed using the Homeostasis Model of Assessment – Insulin Resistance (HOMA‐IR). Amino acids were assayed by examining branched‐chain amino acids (BCAA), tyrosine level, and the ratio of BCAA to tyrosine level (BTR).</p> </sec> <sec id="hepr12213-sec-0003" sec-type="section"> <title>Results</title> <p>HOMA‐IR was significantly correlated with body mass index, platelet count, prothrombin time, hemoglobin, total bilirubin, total protein, albumin, total cholesterol, fasting glucose, BTR (<italic>r</italic> = −0.46, <italic>P</italic> = 0.0001) and tyrosine (<italic>r</italic> = 0.55, <italic>P</italic> < 0.0001). However, BCAA were not significantly correlated with HOMA‐IR (<italic>r</italic> = −0.21, <italic>P</italic> = 0.082). In multivariate analysis, only two factors were identified as independent parameters contributing to a HOMA‐IR of 2.5 or more: total cholesterol (odds ratio [OR], 6.511; 95% confidence interval [95% CI], 1.554–27.284; <italic>P</italic> = 0.010) and tyrosine (OR, 4.839; 95% CI, 1.087–21.549; <italic>P</italic> = 0.039).</p> </sec> <sec id="hepr12213-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Serum tyrosine levels may be associated with IR in patients with HCV‐related chronic liver disease.</p> </sec> </abstract>