Splenic lymph follicles generate immunoglobulin M‐producing B cells in primary biliary cirrhosis. Issue 10 (7th January 2014)

• Record Type: Journal Article
• Authors: Kikuchi, Kentaro; Tsuneyama, Koichi; Yamada, Hanae; Kajiyama, Yusuke; Matsumoto, Kotaro; Tsunashima, Hiromichi; Yamashita, Risa; Takai, Atsuko; Negishi, Masatsugu; Hara, Masumi; Moritoki, Yuki; Miyakawa, Hiroshi
• Is Part Of: Hepatology research. Volume 44:Issue 10(2014:Oct.)
• Page Start: E253
• Page End: E256
• Publication Date: 2014-01-07
• Subjects: Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12231
• Languages: English
• ISSNs: 1386-6346

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hepr12231-sec-0001" sec-type="section"> <title>Aim</title> <p>To reveal the site of immunoglobulin (Ig)M production in primary biliary cirrhosis (PBC) we performed immunohistochemical analysis on spleens collected from patients with PBC.</p> </sec> <sec id="hepr12231-sec-0002" sec-type="section"> <title>Methods</title> <p>Splenic tissue samples were collected at the time of the autopsy from patients with hepatic failure. Immunostaining for IgM, CD21 and CXCL13 were performed using the splenic tissue samples.</p> </sec> <sec id="hepr12231-sec-0003" sec-type="section"> <title>Results</title> <p>The samples from five out of eight cases with PBC but not in eight cases of chronic hepatitis C virus infection showed accumulation of IgM positive cells in CD21 positive lymph follicles. The CXCL13 positive cells also accumulated in the center of the lymph follicles where the IgM positive cells accumulated.</p> </sec> <sec id="hepr12231-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The present results suggest that excess IgM is produced from the spleen of PBC. Furthermore, it was suggested that CXCL13 positive follicular dendritic cells possibly contribute to this process.</p> </sec> </abstract>