Adiponectin predicts MMP‐2 activity independently of obesity. (October 2014)

• Record Type: Journal Article
• Authors: Miksztowicz, Verónica; Fernandez Machulsky, Nahuel; Lucero, Diego; Fassio, Eduardo; Schreier, Laura; Berg, Gabriela
• Is Part Of: European journal of clinical investigation. Volume 44:Number 10(2014:Oct.)
• Page Start: 951
• Page End: 957
• Publication Date: 2014-10
• Subjects: Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12328
• Languages: English
• ISSNs: 0014-2972

Abstract

<abstract abstract-type="main" id="eci12328-abs-0001"> <title>Abstract</title> <sec id="eci12328-sec-0001" sec-type="section"> <title>Background</title> <p>Matrix metalloproteinases (MMPs), especially MMP‐2 and MMP‐9, have been identified in atherosclerotic plaques and have been directly associated with plaque remodelling and vulnerability. Cardiovascular disease (CVD) is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflammatory markers, such as adiponectin and C‐reactive protein (CRP). Our aim was to evaluate the impact of both proteins on MMP‐2 and MMP‐9 behaviour in individuals with IR.</p> </sec> <sec id="eci12328-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>Plasma MMP‐2 and MMP‐9 activity, adiponectin and hs‐CRP concentration and lipoprotein profile were determined in 52 patients with metabolic syndrome (MS) and 27 controls.</p> </sec> <sec id="eci12328-sec-0003" sec-type="section"> <title>Results</title> <p>Patients with MS presented significantly higher MMP‐2 activity than controls: 0·95 ± 0·12 vs. 0·77 ± 0·15 relative units (RU) (<italic>P</italic> < 0·001), while MMP‐9 activity was not detectable. MMP‐2 activity decreased across quartiles of adiponectin, being significantly reduced in individuals with the highest levels of adiponectin in compared with the lowest levels (0·75 ± 0·17 vs. 0·93 ± 0·09 RU, <italic> P</italic> < 0·005). This difference persisted significant after adjusting by obesity markers. MMP‐2 activity was significantly increased in individuals with the highest levels (G3) compared with those with the lowest levels (G1) of hs‐CRP (0·94 ± 0·12 vs. 0·86 ± 0·12, <italic>P</italic> = 0·041)</p> </sec> <sec id="eci12328-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In this study, we observed that adiponectin levels predicted MMP‐2 plasma activity independently of obesity. This finding suggests that the inflammatory process, associated with the highest CVD risk, would be involved in MMPs vascular production.</p> </sec> </abstract>