Effects of adenoid/tonsillectomy on inflammatory response in snoring children with witnessed apnoea. (October 2014)

• Record Type: Journal Article
• Authors: Mutlu, M.; Vuralkan, E.; Yardim Akaydin, S.; Akin, I.; Miser, E.
• Is Part Of: Clinical otolaryngology. Volume 39:Number 5(2014:Oct.)
• Page Start: 266
• Page End: 271
• Publication Date: 2014-10
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1111/coa.12289
• Languages: English
• ISSNs: 1749-4478

Abstract

<abstract abstract-type="main" id="coa12289-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="coa12289-sec-0001" sec-type="section"> <title>Objective</title> <p>The aim of this study was to investigate the clinical significance of preoperative serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), fetuin‐A, cystatin C, adiponectin and tumour necrosis factor‐alpha (TNF‐<italic>α</italic>) levels in children with adenoid/tonsillar hypertrophy and compare these results with postoperative values.</p> </sec> <sec id="coa12289-sec-0002" sec-type="section"> <title>Study design</title> <p>Prospective clinical trial.</p> </sec> <sec id="coa12289-sec-0003" sec-type="section"> <title>Setting</title> <p>Single tertiary care centre.</p> </sec> <sec id="coa12289-sec-0004" sec-type="section"> <title>Participants</title> <p>Thirty‐five children (14 boys and 21 girls) participated in this study.</p> </sec> <sec id="coa12289-sec-0005" sec-type="section"> <title>Main outcome measures</title> <p>The operations were performed with the indication of sleep‐disordered breathing (SDB). Blood samples were taken preoperatively and at 6 months postoperatively to determine the changes in serum high‐sensitivity CRP (hs‐CRP), IL‐6, fetuin‐A, cystatin C, adiponectin and TNF‐<italic>α</italic> levels. Pre‐ and postoperative values of body weights and heights of the participants were recorded preoperatively and at postoperative 6 months.</p> </sec> <sec id="coa12289-sec-0006" sec-type="section"> <title>Results</title> <p>Patients underwent adenoidectomy (<italic>n</italic> = 21) or adenotonsillectomy (<italic>n</italic> = 21). The mean age at surgery was 8.74 ± 3.33 years (range 3–16 years). Mean serum levels of parameters measured preoperatively and at postoperative 6 months. The observed differences between pre‐ and postoperative values were statistically significant (<italic>P</italic> < 0.05), excluding cystatin C levels (<italic>P</italic> > 0.05).</p> </sec> <sec id="coa12289-sec-0007" sec-type="section"> <title>Conclusion</title> <p>High levels of IL‐6, hs‐CRP and TNF‐<italic>α</italic> and low levels of fetuin‐A in serum might have a clinical significance in patients with sleep‐disordered breathing. Levels of cytokines in children with sleep‐disordered breathing because of adenotonsillar disease decreased after surgical treatment. The risks of development of cardiovascular disease are decreased in association with lower levels of cytokines, which are also closely associated with many disease states.</p> </sec> </abstract>