Iron‐Catalyzed C(sp2)H Alkylation of Carboxamides with Primary Electrophiles1. Issue 41 (3rd August 2014)

• Record Type: Journal Article
• Authors: Monks, Brendan M.; Fruchey, Erin R.; Cook, Silas P.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 41(2014)
• Page Start: 11065
• Page End: 11069
• Publication Date: 2014-08-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201406594
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The direct</bold>­ <italic><bold>ortho</bold></italic>­ <bold>alkylation</bold> of 8‐aminoquinoline‐based aryl amides was achieved with primary alkyl bromides in high yields in the presence of an iron catalyst, 1, 2‐bis(diphenylphosphino)ethane (dppe), and PhMgBr in 2‐MeTHF.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh1f8fg6q5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>