Cover Picture: Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae (Angew. Chem. Int. Ed. 40/2014). Issue 40 (30th July 2014) - Müller, Sebastian
Abstract American Foulbrood is a widespread and devastating disease of the honey bee brood caused by the bacterium Paenibacillus larvae. In their Communication on page 10821 ff., R. D. Süssmuth et al. elucidated a fascinating nonribosomal biosynthesis through the isolation and structure elucidation of the antibacterial and antifungal paenilamicins. Furthermore, examination of the secondary metabolites of P. larvae sheds light on the virulence mechanisms.