Vitamin D supplementation could limit T helper‐17 response in multiple sclerosis. Issue 3 (22nd July 2014)

• Record Type: Journal Article
• Authors: Najafipoor, Adeleh; Roghanian, Rasoul; Rahimi, Maryam; Zarkesh‐Esfahani, Sayyed Hamid; Shayegannejad, Vahid
• Is Part Of: Clinical & experimental neuroimmunology. Volume 5:Issue 3(2014)
• Page Start: 336
• Page End: 339
• Publication Date: 2014-07-22
• Subjects: 616.80479
• DOI: 10.1111/cen3.12139
• Languages: English
• ISSNs: 1759-1961

Abstract

<abstract abstract-type="main" id="cen312139-abs-0001"> <title>Abstract</title> <sec id="cen312139-sec-0001" sec-type="section"> <title>Objectives</title> <p>Low vitamin D and high response of T helper‐17 (Th17) are two main risk factors in multiple sclerosis (MS). The purpose of the present study was to investigate whether vitamin D supplementation can reduce Th17 responses and interleukin‐17A (IL‐17A) production.</p> </sec> <sec id="cen312139-sec-0002" sec-type="section"> <title>Methods</title> <p>Serum samples of 17 relapsing–remitting MS patients were collected at onset of disease. They were supplemented with 50 000 IU/week vitamin D<sub>3</sub> for 6 months. After 6 months, sampling was repeated from the patients. The serum level of 25‐hydroxyvitamin D and IL‐17A were measured at baseline, and after 6 months using commercially available enzyme‐linked immunosorbent assay. Statistical analyses were carried out by Wilcoxon test and Spearman's rho correlation coefficient.</p> </sec> <sec id="cen312139-sec-0003" sec-type="section"> <title>Results</title> <p>The levels of 25‐hydroxyvitamin D were generally deficient (29.4%) and insufficient (47%) in the patients at baseline. The initial IL‐17A levels (mean 3.9, standard error 0.28) were significantly decreased after vitamin D supplementation (mean 2.2, standard error 0.18, <italic>P </italic><<italic> </italic>0.0001). Furthermore, a positive correlation was seen between pre‐supplementation IL‐17A levels and reduction after supplementation (Spearman's rho = 0.61, <italic>P </italic>= 0.008).</p> </sec> <sec id="cen312139-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In the present study, it was shown that vitamin D supplementation could reduce the level of IL‐17A in MS patients, and there was an association between these two risk factors in MS disease.</p> </sec> </abstract>