Association between aspirin use and the prevalence of nonalcoholic fatty liver disease: a cross‐sectional study from the Third National Health and Nutrition Examination Survey. Issue 9 (1st September 2014)

• Record Type: Journal Article
• Authors: Shen, H.; Shahzad, G.; Jawairia, M.; Bostick, R. M.; Mustacchia, P.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 40:Issue 9(2014)
• Page Start: 1066
• Page End: 1073
• Publication Date: 2014-09-01
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.12944
• Languages: English
• ISSNs: 0269-2813

Abstract

<abstract abstract-type="main" id="apt12944-abs-0001"> <title>Summary</title> <sec id="apt12944-sec-0001" sec-type="section"> <title>Background</title> <p>Many basic mechanistic studies found that aspirin inhibited multiple pathways involved in non‐alcoholic fatty liver disease (NAFLD) development.</p> </sec> <sec id="apt12944-sec-0002" sec-type="section"> <title>Aim</title> <p>To investigate an association between aspirin use and NAFLD prevalence in the general US population.</p> </sec> <sec id="apt12944-sec-0003" sec-type="section"> <title>Methods</title> <p>We conducted a cross‐sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III). We included 11 416 adults aged 20–74 years who underwent ultrasonography; of those, 2889 were identified as having NAFLD and 8527 as controls. Aspirin use during the month prior to interview was categorised as never use (0 times), occasional use (1–14 times) and regular use (≥15 times).</p> </sec> <sec id="apt12944-sec-0004" sec-type="section"> <title>Results</title> <p>In the multivariate unconditional logistic regression analysis, regular relative to no aspirin use was inversely associated with prevalent NAFLD [odds ratio (OR) = 0.62, 95% confidence interval (CI) 0.51–0.74; <italic>P</italic> for trend = 0.04], a finding that was primarily limited to men (OR = 0.32, 95% CI 0.23–0.45; <italic>P</italic> for interaction < 0.01) and those who were older (>60 years) (OR = 0.21, 95% CI 0.14–0.30; <italic>P</italic> for interaction < 0.01).</p> </sec> <sec id="apt12944-sec-0005" sec-type="section"> <title>Conclusion</title> <p>These findings, from the first human study to investigate an association of aspirin use with NAFLD, suggest that regular aspirin use (≥ 15 times per month) may be associated with a lower prevalence of NAFLD, primarily among men and older patients.</p> </sec> </abstract>