Cation‐mediated electrostatic interaction in collagen–integrin complex1. (21st March 2014)

• Record Type: Journal Article
• Authors: Ansalone, P.; Bottauscio, O.; Manzin, A.; Abel, Marie‐Laure; Rossi, Antonella; Watts, John F.
• Is Part Of: Surface and interface analysis. Volume 46:Number 10/11(2014)
• Page Start: 693
• Page End: 697
• Publication Date: 2014-03-21
• Subjects: Surfaces (Physics) -- Periodicals; Surface chemistry -- Periodicals; Thin films -- Periodicals; 541.33
• DOI: 10.1002/sia.5431
• Languages: English
• ISSNs: 0142-2421

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The paper investigates the electrostatic interactions between organic scaffolds, made of collagen, and a specific family of integrin proteins. We focus the attention on a triple‐helical collagen peptide able to specifically recognize the transmembrane protein integrin α₂β₁, usually involved in cell adhesion processes. The study of molecular adhesion is performed via a boundary element code designed to solve the linearized Poisson–Boltzmann equation. The binding affinity of the two molecular structures is analyzed making reference to the electrostatic complementarity principle. The mediating role of cation Co²⁺ is also discussed. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>