Chemical imaging of the reconstruction of new bone and trace elements inside bioactive glass scaffolds in vivo: a multimodal and quantitative micro‐ion beam analysis. (11th February 2014)

• Record Type: Journal Article
• Authors: Lao, J.; Lacroix, J.; Nohra, J.; Naaman, N.; Sautier, J.‐M.; Jallot, E.; Abel, Marie‐Laure; Rossi, Antonella; Watts, John F.
• Is Part Of: Surface and interface analysis. Volume 46:Number 10/11(2014)
• Page Start: 702
• Page End: 706
• Publication Date: 2014-02-11
• Subjects: Surfaces (Physics) -- Periodicals; Surface chemistry -- Periodicals; Thin films -- Periodicals; 541.33
• DOI: 10.1002/sia.5375
• Languages: English
• ISSNs: 0142-2421

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>An original multimodal analysis is proposed for follow‐up of bone regeneration inside a SiO₂–CaO bioactive glass scaffold <italic>in vivo</italic>. Classic histological studies are conducted in connection with SEM with backscattered electron imaging and micro‐particle induced X‐ray emission ion beam analysis, allowing fine morphological characterization and highly sensitive microanalysis of the scaffold/bone interface. The highly bioactive scaffold is entirely changed into bone mineral after 6 weeks of implantation in sheep mandible; thanks to our proposed methodology, it is possible to highlight subtle differences in mineralization and to distinguish between the mineralized scaffold, the newly formed bone and native bone from the trace metal nutrients content. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>