Association study of interleukin-19 rs2243188 polymorphism with systemic lupus erythematosus in a Chinese population. (September 2014)

• Record Type: Journal Article
• Authors: Ni, Jing; Zhang, Min; Zhu, Yan; Chen, Gui-Mei; Liu, Juan; Zhang, Chao; Li, Lian-Ju; Pan, Hai-Feng; Ye, Dong-Qing
• Is Part Of: Autoimmunity. Volume 47:Number 6(2014)
• Page Start: 378
• Page End: 382
• Publication Date: 2014-09
• Subjects: Autoimmunity -- Periodicals; Autoimmune diseases -- Periodicals; 571.973
• DOI: 10.3109/08916934.2014.914505
• Languages: English
• ISSNs: 0891-6934

Abstract

<abstract> <title>Abstract</title> <p>The purpose of this study was to evaluate whether a single-nucleotide polymorphism (SNP), <italic>rs2243188</italic> of <italic>interleukin-19</italic> (<italic>IL-19</italic>), show significant evidence for association with SLE in a Chinese population. A total of 545 SLE patients and 613 healthy controls were collected in the present study. The genotyping of <italic>IL-19 rs2243188</italic> polymorphism was detected by TaqMan allele discrimination assay on the 7300 real time polymorphism chain reaction system. The minor C allele of <italic>rs2243188</italic>, relative to the major A allele, appeared to have a significantly lower frequency in SLE patients (31.0%) as compared with controls (35.5%) (χ<sup>2</sup> = 5.19, <italic>p</italic> = 0.023). We also discovered a statistical significance in the dominant model (CC + CA versus AA: OR = 0.755, 95% CI = 0.598–0.953, <italic>p</italic> = 0.018). However, no significant difference in genotype distribution was found between SLE patients and controls (<italic>p</italic> = 0.056). Furthermore, an increased frequency of CC genotype were also detected in lupus nephritis (LN) groups as compared with non-LN groups (<italic>p</italic> = 0.024). Besides, the individuals with CC genotype had a 2.201-fold higher risk for the susceptibility to LN than those A allele carriers (AA + CA) (<italic>p</italic> = 0.006). Unfortunately, the analyses on the relationship of <italic>IL-19 rs2243188</italic> with several clinical manifestations of SLE failed to find any significant results. In conclusion, our observations suggested the minor C allele of SNP <italic>rs2243188</italic> might be a protective factor for SLE in a Chinese Han population. Moreover, the subgroup analysis highlighted that <italic>IL-19 rs2243188</italic> SNP was associated with the susceptibility to LN patients.</p> </abstract>