Microjaponin, A New Dihydroagarofuranoid Sesquiterpene from the Stem of Microtropis japonica with Antituberculosis Activity. Issue 8 (August 2014)

• Record Type: Journal Article
• Authors: Chen, Jih‐Jung; Kuo, Wen‐Lung; Chen, Ih‐Sheng; Peng, Chien‐Fang; Sung, Ping‐Jyun; Cheng, Ming‐Jen; Lim, Yun‐Ping
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 8(2014:Aug.)
• Page Start: 1241
• Page End: 1246
• Publication Date: 2014-08
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201400066
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new dihydroagarofuran‐based sesquiterpene, microjaponin (<bold>1</bold>), was isolated from the stem of <italic>Microtropis japonica.</italic> Its structure was determined by in‐depth spectroscopic and mass‐spectrometric analyses. Microjaponin (<bold>1</bold>) exhibited potent <italic>in vitro</italic> antituberculosis activity, with an <italic>MIC</italic> value of 12.5 μg/ml against <italic>Mycobacterium tuberculosis</italic> H₃₇Rv.</p> </abstract>