The ABCG2 gene Q141K polymorphism contributes to an increased risk of gout: A meta-analysis of 2185 cases. Issue 5 (September 2014)

• Record Type: Journal Article
• Authors: Qiu, Ya; Liu, Hua; Qing, Yufeng; Yang, Min; Tan, Xiaoyao; Zhao, Mingcai; Lin, Monica; Zhou, Jingguo
• Is Part Of: Modern rheumatology. Volume 24:Issue 5(2014)
• Page Start: 829
• Page End: 834
• Publication Date: 2014-09
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2013.875639
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> Individual genetic association studies examining the relationship between the <italic>ABCG2</italic> gene polymorphisms and gout have yielded inconsistent results. This study aims to evaluate the association between the <italic>ABCG2</italic> gene variants and gout using meta-analysis.</p> <p> <italic>Materials and methods.</italic> Relevant studies were identified by searching databases extensively. The odds ratio (OR) was calculated using a random-effect or fixed-effect model. A Q statistic was used to evaluate homogeneity, and Egger's test and funnel plot were used to assess publication bias. Subgroup analyses on ethnicities and sex were also performed.</p> <p> <italic>Results.</italic> A total of 7 studies, including 2185 gout patients and 8028 controls from 5 countries or regions, were included and identified for the current meta-analysis. It was found that the A allele or AA genotype of the <italic>ABCG2</italic> Q141K polymorphism (rs2231142) had an increased risk of gout in the general population (A allele, <italic>p</italic> < 0.00001 and AA genotype, <italic>p</italic> < 0.00001, respectively). On the contrary, CC homozygote played a protective role against the risk of gout (<italic>p</italic> < 0.00001). Similar results were found in subgroup analyses. However, there was a significant heterogeneity among studies.</p> <p> <italic>Conclusions.</italic> Existing evidence indicates that the Q141K polymorphism (rs2231142, the A allele and AA genotype) is associated with an increased risk of gout.</p> </abstract>