ITP-QoL Questionnaire for Children with Immune Thrombocytopenia: Italian Version validation's. (1st September 2014)

• Record Type: Journal Article
• Authors: Giordano, Paola; Lassandro, Giuseppe; Giona, Fiorina; Jankovic, Momcilo; Nardi, Margherita; Nobili, Bruno; Notarangelo, Lucia Dora; Russo, Giovanna; Mackensen, Sylvia von
• Is Part Of: Pediatric hematology and oncology. Volume 31:Number 6(2014:Sep.)
• Page Start: 534
• Page End: 547
• Publication Date: 2014-09-01
• Subjects: Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Hematologic Diseases -- Child; Hematologic Diseases -- Infant; Neoplasms -- Child; 618.9215
• DOI: 10.3109/08880018.2014.915443
• Languages: English
• ISSNs: 0888-0018

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Background</italic>: The ITP-QoL is a disease-specific questionnaire for the assessment of health-related quality of life (HRQoL) in children with immune thrombocytopenia (ITP) and their parents. The aim of this study was to test the psychometric characteristics of the ITP-QoL in the Italian pediatric population in terms of validity and reliability. <italic>Procedure</italic>: Children aged 8–16 years with acute or chronic ITP and their parents were recruited in Italy. Participants completed the ITP-QoL together with other patient-reported outcomes (PROs). <italic>Reliability</italic> was calculated using Cronbach's alpha. <italic>Convergent validity</italic> was determined by means of the Pearson correlation coefficients. <italic>Results</italic>: A total of 91 ITP patients, mean age of 12.11 ± 2.47 years, and their parents participated; 61.5% of the patients were female. Two patients had acute ITP and 30.2% had a moderate to severe status of ITP. Cutaneous symptoms were more frequent than mucosal symptoms. Due to item and scale analyses 20 items were deleted from the original ITP-QoL. Internal consistency of the ITP-QoL was found to be good with Cronbach's alpha exceeding <italic>α</italic> = 0.70 for all but one subscale. Concerning convergent validity "moderate" to "high" negative correlations were found between ITP-QoL and KINDL subscales. The ITP-QoL was able to discriminate between clinical subgroups such as number of days lost at school due to ITP and hospitalization. <italic>Conclusions</italic>: Our study was able to demonstrate that the Italian version of ITP-QoL (for children aged 8–16 years) is a valid and reliable instrument for the assessment of HRQoL in children with ITP.</p> </abstract>