Avascular Necrosis of Femoral Head as the Initial Manifestation of CML. (1st September 2014)

• Record Type: Journal Article
• Authors: Kumar, Suresh; Bansal, Deepak; Prakash, Mahesh; Sharma, Prashant
• Is Part Of: Pediatric hematology and oncology. Volume 31:Number 6(2014:Sep.)
• Page Start: 568
• Page End: 573
• Publication Date: 2014-09-01
• Subjects: Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Hematologic Diseases -- Child; Hematologic Diseases -- Infant; Neoplasms -- Child; 618.9215
• DOI: 10.3109/08880018.2013.831961
• Languages: English
• ISSNs: 0888-0018

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Summary</italic>: A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxyurea, followed by imatinib. AVN was managed conservatively; patient demonstrated progressive improvement, though a mild limp in the gait was persisting at 22 months. AVN as the initial manifestation of CML is a rarity. Leukostasis is considered to be the pathophysiological mechanism. In view of the rarity, a case is reported, along with compilation of previously reported cases.</p> </abstract>