Assessment of a portable prothrombin time analyzer (CoaguChek‐XS) in dogs. (15th July 2014)

• Record Type: Journal Article
• Authors: Kelmer, Efrat; Segev, Gilad; Codner, Carolina; Bruchim, Yaron; Klainbart, Sigal; Aroch, Itamar
• Is Part Of: Journal of veterinary emergency and critical care. Volume 24:Number 4(2014:Jul./Aug.)
• Page Start: 455
• Page End: 460
• Publication Date: 2014-07-15
• Subjects: Veterinary emergencies -- Periodicals; Veterinary critical care -- Periodicals; 636.089
• DOI: 10.1111/vec.12200
• Languages: English
• ISSNs: 1479-3261

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="vec12200-sec-0010" sec-type="section"> <title>Objectives</title> <p>To assess the performance of a portable prothrombin time (PT) analyzer (CoaguChek‐XS) in dogs.</p> </sec> <sec id="vec12200-sec-0020" sec-type="section"> <title>Animals</title> <p>Ninety‐seven dogs composed of 20 healthy dogs, 45 ill dogs, and 32 ill dogs with altered coagulation.</p> </sec> <sec id="vec12200-sec-0030" sec-type="section"> <title>Procedures</title> <p>Samples were concurrently obtained and PT was measured using the CoaguChek‐XS and an automated coagulation analyzer. Agreement between methods was assessed using Spearman's correlation and Bland–Altman analysis.</p> </sec> <sec id="vec12200-sec-0040" sec-type="section"> <title>Results</title> <p>The reference interval for PT using the CoaguChek‐XS was 9.6–11.5 s. The CoaguChek‐XS was easy to use, required a small volume of whole blood, and gave results within 1 min. The mean difference in PT between the 2 methods was 2.58 s (SD 3.10), and 94% of the samples fell within limits of agreement. The correlation was moderate, but significant (<italic>r</italic> = 0.35, <italic>P</italic> < 0.001). Sensitivity and specificity of the CoaguCheck‐XS PT compared to analyzer PT were 92% and 56%, respectively, and increased to 95% and 77% on intent to treat basis. The coefficient of variance was 0.72%.</p> <p>The CoaguChek‐XS identified all 8 dogs with anticoagulant rodenticide intoxication, although a discrepancy was noted from the analyzer results. In anemic dogs (PCV≤25%), the CoaguChek‐XS did not display accurate results.</p> </sec> <sec id="vec12200-sec-0050" sec-type="section"> <title>Conclusions</title> <p>The CoaguChek‐XS is a simple, user‐friendly, highly precise PT analyzer. Results had moderate correlation and good agreement with a standard method. It can be used reliably for screening dogs when the PT is normal. However, when the CoaguChek‐XS PT is prolonged or when the PCV is ≤25%, results should be confirmed using a standard method.</p> </sec> </abstract>