Epidermal hydration levels in patients with rosacea improve after minocycline therapy. (5th June 2014)

• Record Type: Journal Article
• Authors: Ní Raghallaigh, S.; Powell, F.C.
• Is Part Of: British journal of dermatology. Volume 171:Number 2(2014:Aug.)
• Page Start: 259
• Page End: 266
• Publication Date: 2014-06-05
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12770
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12770-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12770-list-0001" list-type="bullet"> <list-item> <p>Patients with rosacea have features suggestive of abnormal skin barrier function.</p> </list-item> <list-item> <p>Sebum, pH and hydration levels influence this epidermal homeostasis.</p> </list-item> <list-item> <p>The activity of the epidermal protease enzyme kallikrein 5 is increased in rosacea. Protease enzymes are most active at an alkaline pH.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12770-list-0002" list-type="bullet"> <list-item> <p>Patients with papulopustular rosacea (PPR) have normal sebum casual levels, reduced epidermal hydration levels and a more alkaline centrofacial pH compared with control subjects.</p> </list-item> <list-item> <p>Hydration levels in patients with PPR increase after minocycline treatment, while skin pH and sebum levels remain unchanged.</p> </list-item> </list> </p> </abstract>