Catalytic Enantioselective CH Functionalization of Alcohols by Redox‐Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon. Issue 35 (23rd July 2014)

• Record Type: Journal Article
• Authors: Ketcham, John M.; Shin, Inji; Montgomery, T. Patrick; Krische, Michael J.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 35(2014)
• Page Start: 9142
• Page End: 9150
• Publication Date: 2014-07-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201403873
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The use of alcohols and unsaturated reactants for the redox‐triggered generation of nucleophile–electrophile pairs represents a broad, new approach to carbonyl addition chemistry. Discrete redox manipulations that are often required for the generation of carbonyl electrophiles and premetalated carbon‐centered nucleophiles are thus avoided. Based on this concept, a broad, new family of enantioselective CC coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview.</p> </abstract>