Immunomodulatory effects in the spleen‐injured mice following exposure to titanium dioxide nanoparticles. Issue 10 (16th November 2013)

• Record Type: Journal Article
• Authors: Sang, Xuezi; Fei, Min; Sheng, Lei; Zhao, Xiaoyang; Yu, Xiaohong; Hong, Jie; Ze, Yuguan; Gui, Suxin; Sun, Qingqing; Ze, Xiao; Wang, Ling; Hong, Fashui
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 10(2014)
• Page Start: 3562
• Page End: 3572
• Publication Date: 2013-11-16
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35034
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Immune injuries following the exposure of titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) have been greatly concerned along with the TiO<sub>2</sub> NPs are widely used in pharmacology and daily life. However, very little is known about the immunomodulatory mechanisms in the spleen‐injured mice due to TiO<sub>2</sub> NPs exposure. In this study, mice were continuously exposed to 2.5, 5, or 10 TiO<sub>2</sub> NPs mg kg<sup>−1</sup> body weight for 90 days with intragastric administration to investigate the immunomodulatory mechanisms in the spleen. The findings showed that TiO<sub>2</sub> NPs exposure resulted in significant increases in spleen and thymus indices, and titanium accumulation, in turn led to histopathological changes and splenocyte apoptosis. Furthermore, the exposure of TiO<sub>2</sub> NPs could significantly increase the levels of macrophage inflammatory protein (MIP)−1α, MIP‐2, Eotaxin, monocyte chemotactic protein‐1, interferon‐γ, vascular cell adhesion molecule‐1, interleukin‐13, interferon‐γ‐inducible protein‐10, migration inhibitory factor, CD69, major histocompatibility complex, protein tyrosine phosphatase, protein tyrosine kinase 1, basic fibroblast growth factor, Fasl, and GzmB expression, whereas markedly decrease the levels of NKG2D, NKp46, 2B4 expression involved in immune responses, lymphocyte healing and apoptosis. These findings would better understand toxicological effects induced by TiO<sub>2</sub> NPs exposure. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3562–3572, 2014.</p> </abstract>