Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait. Issue 1 (30th July 2013)

• Record Type: Journal Article
• Authors: Hill, Sarah Catherine; Mohammad, Talal Ramadan; Kivisild, Toomas
• Is Part Of: American journal of physical anthropology. Volume 152:Issue 1(2013)
• Page Start: 140
• Page End: 144
• Publication Date: 2013-07-30
• Subjects: Physical anthropology -- Periodicals; Anthropology -- Periodicals; Anthropologie physique -- Périodiques; 599.9
• DOI: 10.1002/ajpa.22313
• Languages: English
• ISSNs: 0002-9483

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Lactase persistence (LP)—the ability to digest lactose in adulthood—is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the <italic>LCT</italic> (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic‐pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the −<italic>13, 915*G</italic> allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the −<italic>13, 915*G</italic> allele frequency among the Kuwaiti Bedouin may be higher than among non‐Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift. Am J Phys Anthropol 152:140–144, 2013. © 2013 Wiley Periodicals, Inc.</p> </abstract>