Dressed not to kill: CD16+ monocytes impair immune defence against tuberculosis. Issue 2 (14th February 2013)

• Record Type: Journal Article
• Authors: Lugo‐Villarino, Geanncarlo; Neyrolles, Olivier
• Is Part Of: European journal of immunology. Volume 43:Issue 2(2013:Feb.)
• Page Start: 327
• Page End: 330
• Publication Date: 2013-02-14
• Subjects: Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201243256
• Languages: English
• ISSNs: 0014-2980

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Monocytes are blood leukocytes that can differentiate into several phagocytic cell types, including DCs, which are instrumental to the inflammatory response and host defence against microbes. A study published in this issue of the <italic>European Journal of Immunology</italic> by Balboa et al. [Eur. J. Immunol. 2013. 43: 335‐347] suggests that a shift of the CD16⁻ monocyte population toward a CD16⁺ subpopulation may represent an immune evasion strategy that ultimately favors persistence of <italic>Mycobacterium tuberculosis</italic>. Together with other recent reports, the article by Balboa et al. sheds new light on the function of CD16⁺ monocytes in health and disease; in this commentary, we discuss the implications stemming from these findings.</p> </abstract>