Development of CD27+ marginal zone B cells requires GALT. Issue 6 (19th April 2013)

• Record Type: Journal Article
• Authors: Yeramilli, Venkata A.; Knight, Katherine L.
• Is Part Of: European journal of immunology. Volume 43:Issue 6(2013:Jun.)
• Page Start: 1484
• Page End: 1488
• Publication Date: 2013-04-19
• Subjects: Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201243205
• Languages: English
• ISSNs: 0014-2980

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross‐reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27⁺CD23⁻. In rabbits in which organized gut‐associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23⁺ follicular (FO) B cells and almost no CD27⁺ MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.</p> </abstract>