Bevacizumab (BVZ)‐associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT‐11). Issue 23 (19th September 2013)

• Record Type: Journal Article
• Authors: Fangusaro, Jason; Gururangan, Sridharan; Poussaint, Tina Young; McLendon, Roger E.; Onar‐Thomas, Arzu; Warren, Katherine E.; Wu, Shengjie; Packer, Roger J.; Banerjee, Anu; Gilbertson, Richard J.; Jakacki, Regina; Gajjar, Amar; Goldman, Stewart; Pollack, Ian F.; Friedman, Henry S.; Boyett, James M.; Kun, Larry E.; Fouladi, Maryam
• Is Part Of: Cancer. Volume 119:Issue 23(2013)
• Page Start: 4180
• Page End: 4187
• Publication Date: 2013-09-19
• Subjects: Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28343
• Languages: English
• ISSNs: 0008-543X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cncr28343-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>The incidence and spectrum of acute toxicities related to the use of bevacizumab (BVZ)‐containing regimens in children are largely unknown. This report describes the adverse events in a recently completed large phase 2 trial of BVZ plus irinotecan (CPT‐11) in children with recurrent central nervous system tumors.</p> </sec> <sec id="cncr28343-sec-0002" sec-type="section"> <title>METHODS</title> <p>Pediatric Brain Tumor Consortium trial‐022 evaluated the efficacy and toxicity of BVZ (10 mg/kg administered intravenously) as a single agent for 2 doses given 2 weeks apart and then combined with CPT‐11 every 2 weeks (1 course = 4 weeks) in children with recurrent central nervous system tumors. Children were treated until they experienced progressive disease, unacceptable toxicity or completed up to a maximum of 2 years of therapy. Toxicities were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0. Patients who received at least 1 dose of BVZ were included for toxicity assessment.</p> </sec> <sec id="cncr28343-sec-0003" sec-type="section"> <title>RESULTS</title> <p>Between October 2006 and June 2010, 92 patients evaluable for toxicity were enrolled and received 687 treatment courses. The most common toxicities attributable to BVZ included grade I‐III hypertension (38% of patients), grade I‐III fatigue (30%), grade I‐II epistaxis (24%), and grade I‐IV proteinuria (22%). Twenty‐two patients (24%) stopped therapy due to toxicity.</p> </sec> <sec id="cncr28343-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>The combination of BVZ and CPT‐11 was fairly well‐tolerated, and most severe BVZ‐related toxicities were rare, self‐limiting, and manageable. <bold><italic>Cancer</italic> 2013</bold>;119:4180–4187. ©<italic>2013 American Cancer Society</italic>.</p> </sec> </abstract>