Marginal treatment benefit in anaplastic thyroid cancer. Issue 17 (9th July 2013)

• Record Type: Journal Article
• Authors: Haymart, Megan R.; Banerjee, Mousumi; Yin, Huiying; Worden, Francis; Griggs, Jennifer J.
• Is Part Of: Cancer. Volume 119:Issue 17(2013)
• Page Start: 3133
• Page End: 3139
• Publication Date: 2013-07-09
• Subjects: Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28187
• Languages: English
• ISSNs: 0008-543X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cncr28187-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Because anaplastic thyroid cancer is a rare malignancy with a high mortality rate, the benefit of multimodality treatment was evaluated.</p> </sec> <sec id="cncr28187-sec-0002" sec-type="section"> <title>METHODS</title> <p>Overall survival was determined in the 2742 patients captured by the National Cancer Database who were diagnosed with anaplastic thyroid cancer between 1998 and 2008. Kaplan‐Meier analysis and then Cox proportional hazard regression was performed, controlling for patient characteristics and treatment.</p> </sec> <sec id="cncr28187-sec-0003" sec-type="section"> <title>RESULTS</title> <p>Only older age (adjusted hazard ratio [AHR] for ≥ 85 years = 3.43, 95% confidence interval [CI] = 2.34‐5.03; for 75‐84 years, AHR = 2.85, 95% CI = 1.97‐4.11; for 65‐74 years, AHR = 2.20, 95% CI = 1.53‐3.15; for 45‐64 years, AHR = 2.08, 95% CI = 1.47‐2.95) and omission of treatment were associated with greater mortality (omission of surgery: AHR = 1.79, 95% CI = 1.61‐1.99; omission of radiation therapy: AHR = 1.56; 95% CI = 1.41‐1.73; and omission of chemotherapy: AHR = 1.28, 95% CI = 1.15‐1.43). In subgroup analysis of patients with American Joint Committee on Cancer stage IVA, IVB, and IVC anaplastic thyroid cancer, combination therapy with surgery, radiation, and chemotherapy was associated a difference in median survival of months.</p> </sec> <sec id="cncr28187-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>Multimodality management of anaplastic thyroid cancer results in a marginal treatment benefit. The poor overall survival of all anaplastic thyroid cancer patients, regardless of treatment, emphasizes the need for informed patients whose preferences are incorporated into treatment decision‐making. <bold><italic>Cancer</italic> 2013;119:3133–3139</bold>. © <italic>2013 American Cancer Society</italic>.</p> </sec> </abstract>