Enantioselective Hydrogenation of the Double Bond of Exocyclic α, β‐Unsaturated Carbonyl Compounds Catalyzed by Iridium/H8‐BINOL‐Derived Phosphine‐Oxazoline Complexes. Issue 7 (16th April 2014)

• Record Type: Journal Article
• Authors: Li, Qing; Wan, Pin; He, Yuwei; Zhou, Yougui; Li, Lanning; Chen, Bin; Duan, Kun; Cao, Rihui; Zhou, Zhongyuan; Qiu, Liqin
• Is Part Of: Asian journal of organic chemistry. Volume 3:Issue 7(2014:Jul.)
• Page Start: 774
• Page End: 783
• Publication Date: 2014-04-16
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201402011
• Languages: English
• ISSNs: 2193-5807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>H₈‐BINOL‐derived phosphine‐oxazolines complexed with iridium were successfully applied for the asymmetric hydrogenation of the carbon‐carbon double bond of exocyclic α, β‐unsaturated carbonyl compounds. A valuable series of α‐chiral cyclic ketones, lactones, and lactams were therefore provided via the reaction in high yields and good to excellent enantioselectivity of up to 95 % <italic>ee</italic>. The effects of the ligands and substrate structures on the asymmetric catalysis were also discussed.</p> </abstract>