One‐Pot Sandmeyer Trifluoromethylation and Trifluoromethylthiolation. Issue 10 (20th June 2014)

• Record Type: Journal Article
• Authors: Bayarmagnai, Bilguun; Matheis, Christian; Risto, Eugen; Goossen, Lukas J.
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 10(2014)
• Page Start: 2343
• Page End: 2348
• Publication Date: 2014-06-20
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400340
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Practical one‐pot procedures were developed for both Sandmeyer‐type trifluoromethylations and trifluoromethylthiolations. Starting from broadly available (hetero)aromatic amines, various benzotrifluorides were synthesized in high yields <italic>via in situ</italic> diazotization and copper‐mediated trifluoromethylation using the inexpensive Ruppert–Prakash trifluoromethylating reagent. In the presence of sodium thiocyanate as a sulfur source, aryl trifluoromethyl thioethers are exclusively formed.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghnnqq0kz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>