Cover Picture: A New Pathway of DNA G‐Quadruplex Formation (Angew. Chem. Int. Ed. 19/2014). Issue 19 (3rd April 2014)

• Record Type: Journal Article
• Authors: Čeru, Slavko; Šket, Primož; Prislan, Iztok; Lah, Jurij; Plavec, Janez
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 19(2014)
• Page Start: 4727
• Page End: 4727
• Publication Date: 2014-04-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201401133
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic> <bold>Guanine‐rich DNA sequences</bold> </italic> can self‐assemble into specific pre‐organized DNA structures, where two‐by‐two guanine residues shown as "duets" are involved in GG N1‐carbonyl symmetric base pairs. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 4881 ff., </ext-link> J. Lah, J. Plavec, and co‐workers demonstrate the transition of these "duets" into guanine‐quartets, presented as a "string quartet" when interacting with cations, such as potassium ions. This rearrangement consequently leads to formation of G‐quadruplex structures.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg5nnq0wjg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>