A novel mechanism for cyclic adenosine monophosphate–mediated memory formation: Role of amyloid beta. Issue 4 (14th April 2014)

• Record Type: Journal Article
• Authors: Ricciarelli, Roberta; Puzzo, Daniela; Bruno, Olga; Canepa, Elisa; Gardella, Elena; Rivera, Daniela; Privitera, Lucia; Domenicotti, Cinzia; Marengo, Barbara; Marinari, Umberto Maria; Palmeri, Agostino; Pronzato, Maria Adelaide; Arancio, Ottavio; Fedele, Ernesto
• Is Part Of: Annals of neurology. Volume 75:Issue 4(2014:Apr.)
• Page Start: 602
• Page End: 607
• Publication Date: 2014-04-14
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.24130
• Languages: English
• ISSNs: 0364-5134

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Cyclic adenosine monophosphate (cAMP) regulates long‐term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aβ production. Ann Neurol 2014;75:602–607</p> </abstract>