Should We Reconsider Lung Transplantation Through Uncontrolled Donation After Circulatory Death?. Issue 4 (6th February 2014)

• Record Type: Journal Article
• Authors: Suzuki, Y.; Tiwari, J. L.; Lee, J.; Diamond, J. M.; Blumenthal, N. P.; Carney, K.; Borders, C.; Strain, J.; Alburger, G. W.; Jackson, D.; Timar, J.; Berg, J.; Hasz, R. D.; Cantu, E.
• Is Part Of: American journal of transplantation. Volume 14:Issue 4(2014:Apr.)
• Page Start: 966
• Page End: 971
• Publication Date: 2014-02-06
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.12633
• Languages: English
• ISSNs: 1600-6135

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ajt12633-sec-0001" sec-type="section"> <p>Lung transplantation through <italic>controlled</italic> donation after circulatory death (cDCD) has slowly gained universal acceptance with reports of equivalent outcomes to those through donation after brain death. In contrast, <italic>uncontrolled</italic> DCD (uDCD) lung use is controversial and requires ethical, legal and medical complexities to be addressed in a limited time. Consequently, uDCD lung use has not previously been reported in the United States. Despite these potential barriers, we present a case of a patient with multiple gunshot wounds to the head and the body who was unsuccessfully resuscitated and ultimately became an uDCD donor. A cytomegalovirus positive recipient who had previously consented for CDC high‐risk, DCD and participation in the NOVEL trial was transplanted from this uDCD donor, following 3 h of <italic>ex vivo</italic> lung perfusion. The postoperative course was uneventful, and the recipient was discharged home on day 9. While this case represents a "best‐case scenario, " it illustrates a method for potential expansion of the lung allograft pool through uDCD after unsuccessful resuscitation in hospitalized patients.</p> </sec> </abstract>