Combining the serum pepsinogen level and Helicobacter pylori antibody test for predicting the histology of gastric neoplasm. Issue 6 (June 2014)

• Record Type: Journal Article
• Authors: Choi, Hong Seok; Lee, Sun‐Young; Kim, Jeong Hwan; Sung, In‐Kyung; Park, Hyung Seok; Shim, Chan Sup; Jin, Choon Jo
• Is Part Of: Journal of digestive diseases. Volume 15:Issue 6(2014:Jun.)
• Page Start: 293
• Page End: 298
• Publication Date: 2014-06
• Subjects: Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; 616.3
• DOI: 10.1111/1751-2980.12144
• Languages: English
• ISSNs: 1751-2972

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cdd12144-sec-0001" sec-type="section"> <title>Objective</title> <p>To determine whether the combination test of serum pepsinogen (PG) levels and <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) antibody was effective for predicting the incidence and histology of gastric neoplasms.</p> </sec> <sec id="cdd12144-sec-0002" sec-type="section"> <title>Methods</title> <p>This study included asymptomatic Korean adults who underwent esophagogastroduodenoscopy with blood tests for PG levels and <italic>H. pylori</italic> immunoglobulin G antibody test on the same day. Participants with extragastric malignancy, history of <italic>H. pylori</italic> eradication or gastric neoplasms, or recent antacid medication were excluded. Gastric atrophy was defined as a serum PG I/II ratio ≤3.0 and PG I ≤70 ng/mL. The participants were classified into four groups according to the presence (+) or absence (−) of gastric atrophy and <italic>H. pylori</italic> infection.</p> </sec> <sec id="cdd12144-sec-0003" sec-type="section"> <title>Results</title> <p>Of the 3328 included participants, 17 were incidentally diagnosed as having either gastric adenoma or carcinoma. The incidence of gastric neoplasm was highest in the gastric atrophy (+)/H. pylori (−) group (4.17%; OR 25.8, <italic>P</italic> = 0.009), but the neoplasm exhibited the least advanced histology. The gastric atrophy (−)/H. pylori (−) group exhibited the lowest incidence of gastric neoplasm (0.17%) but the most advanced histology.</p> </sec> <sec id="cdd12144-sec-0004" sec-type="section"> <title>Conclusion</title> <p>A combination of serum PG levels and <italic>H. pylori</italic> antibody test is useful for detecting gastric neoplasms based on the slow gastric carcinogenesis pathway progressing from gastric adenoma to Lauren's intestinal‐type gastric cancer, but not for those with advanced histology such as Lauren's diffuse‐type gastric cancer.</p> </sec> </abstract>