Cutaneous B‐lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis. Issue 6 (8th November 2014)

• Record Type: Journal Article
• Authors: Bomken, Simon; Haigh, Shaun; Bown, Nick; Carey, Peter; Wood, Katrina; Windebank, Kevin
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 6(2015:Jun.)
• Page Start: 1055
• Page End: 1057
• Publication Date: 2014-11-08
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25318
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25318-sec-0001" sec-type="section"> <p>Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B‐lymphoblastic lymphoma. Re‐analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate <italic>IL3/IgH@</italic> fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B‐lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia. Pediatr Blood Cancer 2015;62:1055–1057. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>