Incidental diagnosis of diffuse intrinsic pontine glioma in children. Issue 6 (16th January 2015)

• Record Type: Journal Article
• Authors: Wright, Karen D.; Sabin, Noah D.; Cheuk, Daniel; McNall‐Knapp, RenéY.; Shurtleff, Sheila A.; Gajjar, Amar; Broniscer, Alberto
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 6(2015:Jun.)
• Page Start: 1081
• Page End: 1083
• Publication Date: 2015-01-16
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25408
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25408-sec-0001" sec-type="section"> <p>Children with diffuse intrinsic pontine glioma (DIPG) have a short onset, rapidly progressive neurologic decline before diagnosis. Therefore, incidental diagnosis of such an aggressive cancer is counterintuitive, yet our experience shows DIPG may occur as part of a spectrum of incidentally diagnosed pediatric brain cancers. Although children with incidentally diagnosed DIPG may experience a longer survival, it remains a potentially deadly cancer despite treatment with radiotherapy. Histologic confirmation is warranted when feasible in such patients to confirm diagnosis. Moreover, recent advances in genome‐wide analyses may suggest incidentally diagnosed DIPGs are biologically distinct from the majority of these cancers. Pediatr Blood Cancer 2015;62:1081–1083. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>