Lung transplantation in chronic obstructive pulmonary disease: long‐term survival, freedom from bronchiolitis obliterans syndrome, and factors influencing outcome. (5th March 2015)

• Record Type: Journal Article
• Authors: Zeriouh, Mohamed; Mohite, Prashant N.; Sabashnikov, Anton; Zych, Bartlomiej; Patil, Nikhil P.; Garcia‐Saez, Diana; Koch, Achim; Ghodsizad, Ali; Weymann, Alexander; Soresi, Simona; Wittwer, Thorsten; Choi, Yeong‐Hoon; Wippermann, Jens; Wahlers, Thorsten; Popov, Aron‐Frederik; Simon, André R.
• Is Part Of: Clinical transplantation. Volume 29:Number 4(2015)
• Page Start: 383
• Page End: 392
• Publication Date: 2015-03-05
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12528
• Languages: English
• ISSNs: 0902-0063

Abstract

<abstract abstract-type="main" id="ctr12528-abs-0001"> <title>Abstract</title> <sec id="ctr12528-sec-0001" sec-type="section"> <title>Objectives</title> <p>Lung transplantation (LTx) remains the definitive treatment for end‐stage lung failure, whereas chronic obstructive pulmonary disease (COPD) represents one of the main diagnoses leading to the indication for a transplant. We sought to assess long‐term outcomes after LTx in patients diagnosed with COPD and analyze factors influencing outcome in this frequent patient cohort.</p> </sec> <sec id="ctr12528-sec-0002" sec-type="section"> <title>Methods</title> <p>Between January 2007 and November 2013, a total of 88 LTx were performed in patients with COPD in our institution. Patients with emphysema associated with alpha1‐antitrypsin deficiency were excluded from this observation. The study design was a retrospective review of the prospectively collected data. A large number of pre‐, intra‐, and postoperative variables were analyzed including long‐term survival and freedom from bronchiolitis obliterans syndrome (BOS). Furthermore, impact of different variables on survival was analyzed.</p> </sec> <sec id="ctr12528-sec-0003" sec-type="section"> <title>Results</title> <p>Preoperative donor data indicated a large proportion of marginal donors. While the overall cumulative survival after six yr was 57.4%, the results in terms of BOS‐free survival in long‐term follow‐up were 39.7% after six yr. Patients with COPD were also associated with a low incidence (2.3%) of the need for postoperative extracorporeal life support (ECLS).</p> </sec> <sec id="ctr12528-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Long‐term results after LTx in patients with COPD are acceptable with excellent survival, freedom from BOS, and low use of ECLS postoperatively despite permanently increasing proportion of marginal organs used.</p> </sec> </abstract>