Incidence and remission of urinary incontinence at midlife: a cohort study. (24th July 2014)

• Record Type: Journal Article
• Authors: Legendre, G; Ringa, V; Panjo, H; Zins, M; Fritel, X
• Is Part Of: BJOG. Volume 122:Number 6(2015:Jun.)
• Page Start: 816
• Page End: 824
• Publication Date: 2014-07-24
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.12990
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" id="bjo12990-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo12990-sec-0001" sec-type="section"> <title>Objective</title> <p>Urinary incontinence (UI) is often considered to be an age‐related disease that develops gradually as women grow older. Much remains to be learnt about factors that promote its incidence or its remission. Our objective was to assess its incidence and risk factors.</p> </sec> <sec id="bjo12990-sec-0002" sec-type="section"> <title>Design</title> <p>Longitudinal cohort study.</p> </sec> <sec id="bjo12990-sec-0003" sec-type="section"> <title>Setting</title> <p>French GAZEL cohort.</p> </sec> <sec id="bjo12990-sec-0004" sec-type="section"> <title>Population</title> <p>A cohort of 4127 middle‐aged women (aged 47–52 years at baseline) over an 18‐year period (1990–2008).</p> </sec> <sec id="bjo12990-sec-0005" sec-type="section"> <title>Methods</title> <p>UI was defined as 'difficulty retaining urine'. The question was asked at baseline and repeated every 3 years over an 18‐year period. Two groups (UI incidence and remission) were analysed according to status at baseline (continent or incontinent). A multivariable analysis (Cox model) was used to estimate the risk factors for UI incidence and remission.</p> </sec> <sec id="bjo12990-sec-0006" sec-type="section"> <title>Main outcome measures</title> <p>Annual incidence and remission rates and risk factors for UI incidence and remission.</p> </sec> <sec id="bjo12990-sec-0007" sec-type="section"> <title>Results</title> <p>The annual incidence and remission rates for UI were 3.3% and 6.2%, respectively. High educational level (hazard ratio [HR] = 1.28; 95% confidence interval [95% CI] = 1.05–1.55), parity, i.e. at least one baby versus no baby (HR = 1.64; 95% CI = 1.19–2.27), menopause (HR = 5.44; 95% CI = 4.47–6.63), weight gain, i.e. for each kilogram change in weight (HR = 1.00; 95% CI = 1.00–1.02), onset of depressive symptoms (HR = 1.31; 95% CI = 1.09–1.57) and impairment in health‐related quality of life incidence (social isolation dimension [HR = 1.29; 95% CI = 1.04–1.60] and energy dimension [HR = 1.41; 95% CI = 1.17–1.70]) were associated with an increased probability of UI. The factors associated with persistent UI were age (HR = 0.58; 95% CI = 0.55–0.61), weight gain (HR = 0.99; 95% CI = 0.98–0.99) and transition to menopausal status (HR = 1.54; 95% CI = 1.19–1.99).</p> </sec> <sec id="bjo12990-sec-0008" sec-type="section"> <title>Conclusions</title> <p>Our study suggests that, in our population of middle‐aged women, age, menopause, weight gain, onset of depression and impaired health‐related quality of life may promote UI.</p> </sec> </abstract>